Citrate in human body
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In the human body, Citrate serves as a vital regulatory molecule in liver metabolism. It activates enzymes that promote glucose and lipid synthesis while inhibiting glycolysis to manage energy and biosynthesis pathways.
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‍Simulation to optimize the Cirtate Dose in human body
This simulation provides a description of Citrate concentration in human based on the model published in a paper by Li et.al. [1] article. This app finds a dose that will maintain a concentration of Citrate between Cmin and Cmax.
The optimization is done with the Brent 1D algorithm, as implemented in optim. The result is shown in a plot with three concentration profiles (one for 30 min interdose interval, one for 60 min, one for 120 min) and the optimal dose amounts.

Input parameters
In this simulation you can define the starting time point of treatment, the starting time point of simulation and ending time point of the simulation. The most important inputs are the Cmin and CMax, which define the desired minimum and maximum concentration of the Citrate in the body.

[1] Li, Z., D. M. Erion, and T. S. Maurer. "Model‐based assessment of plasma citrate flux into the liver: implications for NaCT as a therapeutic target." CPT: pharmacometrics & systems pharmacology 5.3 (2016): 132-139.